Endocrine Abstracts

The glucagon-like peptide-1 receptor (GLP-1R) is a G protein-coupled receptor (GPCR) expressed in various tissues such as brain and pancreas where it contributes to the regulation of energy expenditure and metabolism. Due to its involvement in glucose-dependent release of insulin from pancreatic beta cells, the GLP-1R has become a blockbuster target for the treatment of type 2 diabetes. Despite this, debate still exists about the exact distribution of the GLP-1R throughout the...